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Her other films include The Doors (1991), When a Man Loves a Woman (1994), Courage Under Fire (1996), Addicted to Love (1997), City of Angels (1998), Proof of Life (2000), and The Women (2008). She has two sisters, Dana and Annie, and a brother, musician Andrew Hyra, a member of the band Billy Pilgrim.
In 2015, she made her directorial debut with Ithaca, a film in which she also acted. Her parents divorced in 1976 when she was 15 years old.
Ryan began her acting career in 1981 in minor roles, before joining the cast of the CBS soap opera As the World Turns in 1982.
Subsequently, she began to appear in supporting roles in films during the mid-1980s, achieving recognition in independent movies such as Promised Land (1988) before her performance in the Rob Reiner-directed romantic comedy When Harry Met Sally...